In November 2022, Italy's Ministry of Health reported that a 100-year-old woman's liver was successfully transplanted to another patient, marking the first time such a procedure was carried out from an elderly donor. The donor was 100 years, 10 months, and one day. This was the first ultra-centenarian in the world to donate her organs after death. Recent evidences indicate that organs from older donors are no longer rejected solely because of their age, especially in liver transplant programs.

The donation was carried out at San Giovanni di Dio Hospital in Florence. Her liver was donated to a patient on the waiting list at the University of Pisa Hospital. Five other cases of 97-year-olds have previously been recorded as the oldest organ donors, including the previous record of 97 years and 7 months carried out in Italy in 2021.