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“Restored” living donor kidneys used for Transplantation
The eternal shortage of organs for transplantation means that all avenues to utilise a donated organ should be explored. Mannami M et al. (2008) have investigated one such avenue (as reported in the Am J Transplant 8:811-818 and Nature Clinical Practice Nephrology (2008) 4, 292 doi:10.1038/ncpneph0817) - the ex vivo “restoration” of live-donor kidneys; the kidneys in question had some form of pathology that needed to be dealt with prior to transplantation.
The study was carried out from January 1991 to September 2006. In all, 42 kidneys from 38 patients (age 20–77 years; mean age 60.6 years) were studied. These kidneys with benign pathologies, small renal cell carcinoma, ureteral cancer, aneurysm, ureteral stenosis or severe nephrotic syndrome were removed via simple nephrectomy. The kidney lesions were then excised and/or repaired before transplantation of the kidneys into 39 recipients (age 23–69 years; mean age 50.0 years). The risks of the approach were extensively discussed with both the donors and the recipients before the procedures. Recipients were followed up for 12–202 months (mean 69.7 months) after surgery. There were no recurrences of renal cell carcinoma in the patients who received kidneys from donors who had this disease. Likewise, none of the recipients of kidneys from donors who had nephrotic syndrome developed the syndrome. There was one recurrence of ureteral cancer in a transplanted kidney, 15 months after surgery. Recipient survival rates at 1, 5 and 10 years were 92.9%, 79.3% and 63.8%, respectively, and the corresponding graft survival rates were 78.6%, 51..8%, and 42.7%.
The authors conclude that this approach might increase the opportunities for renal transplantation in countries in which deceased donor kidneys are scarce.
- Shroff S, Navin S. “Restored” living donor kidneys used for Transplantation. Indian Transplant Newsletter Vol. 8 Issue NO.: 26 (Feb-Jun 2008)
- Shroff S, Navin S. “Restored” living donor kidneys used for Transplantation. Indian Transplant Newsletter Vol. 8 Issue NO.: 26 (Feb-Jun 2008). Available at:
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- Keywords: Living donor, Kidney, Transplantation